Lack of probenecid effect on nonrenal excretion of ceftriaxone in anephric patients

Probenecid has been shown to decrease renal and biliary excretion of organic acids. In a randomized crossover study, the effect of coadministered probenecid on nonrenal excretion of ceftriaxone was studied in six functionally anephric patients in whom ceftriaxone is eliminated exclusively by nonrena...

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Bibliographic Details
Published inJournal of clinical pharmacology Vol. 30; no. 5; p. 449
Main Authors Patel, I H, Soni, P P, Carbone, J J, Audet, P R, Morrison, G, Gibson, G A
Format Journal Article
LanguageEnglish
Published England 01.05.1990
Subjects
Adult
Ceftriaxone - administration & dosage
Ceftriaxone - blood
Ceftriaxone - pharmacokinetics
Chromatography, High Pressure Liquid
Humans
Kidney Failure, Chronic - metabolism
Middle Aged
Probenecid - pharmacology
Random Allocation
Time Factors
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Summary:Probenecid has been shown to decrease renal and biliary excretion of organic acids. In a randomized crossover study, the effect of coadministered probenecid on nonrenal excretion of ceftriaxone was studied in six functionally anephric patients in whom ceftriaxone is eliminated exclusively by nonrenal or presumably by biliary excretion. Each patient received 0.5 g IV ceftriaxone without and with probenecid (0.5 g at 10 and 2 hours prior to ceftriaxone and 0.5 g q12h X 3 doses post ceftriaxone). Serial blood samples were collected over 48 hours and plasma analyzed for ceftriaxone by high performance liquid chromatography (HPLC). Pharmacokinetic analysis was based on a model-independent approach. Probenecid did not significantly affect the disposition of ceftriaxone in this study, thus suggesting that nonrenal excretion of ceftriaxone is not inhibited by probenecid.
ISSN:0091-2700
1552-4604
DOI:10.1002/j.1552-4604.1990.tb03484.x