The effects of fetal energy depletion on amniotic fluid concentrations of amino acids, organic acids and related metabolites

Concentrations of amino and organic acids, phosphate, sulphate, gluconic acid and gluconolactone were measured in amniotic fluid samples which contained either normal or raised hypoxanthine concentrations. In this way, the effect of mild fetal ATP depletion could be determined. The effects of this m...

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Bibliographic Details
Published inJournal of inherited metabolic disease Vol. 11; no. 1; p. 103
Main Authors Harkness, R A, Purkiss, P, Duffy, S, Chalmers, R A, Jones, M
Format Journal Article
LanguageEnglish
Published United States 01.03.1988
Subjects
Adenosine Triphosphate - metabolism
Amino Acids - analysis
Amniotic Fluid - analysis
Arginine - analysis
Aspartic Acid - analysis
Asphyxia Neonatorum - diagnosis
Diagnosis, Differential
Female
Fetus - metabolism
Humans
Hypoxanthine
Hypoxanthines - analysis
Infant, Newborn
Metabolism, Inborn Errors - diagnosis
Ornithine - analysis
Pregnancy
Uridine - analysis
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Summary:Concentrations of amino and organic acids, phosphate, sulphate, gluconic acid and gluconolactone were measured in amniotic fluid samples which contained either normal or raised hypoxanthine concentrations. In this way, the effect of mild fetal ATP depletion could be determined. The effects of this mild asphyxia were to raise concentrations of phenylalanine, tyrosine, lysine, glycine, phosphate, sulphate, gluconic acid and glucono-1,5-lactone. However, concentrations of a variety of other metabolites were unchanged; thus no diagnostic confusion should arise with organic acidurias in mild asphyxia in contrast to the biochemical mimickry produced by severe asphyxia. Since clinically normal parturition can produce changes in amniotic fluid, urine from newborn or cord blood may not reflect the metabolic balance in utero.
ISSN:0141-8955
DOI:10.1007/BF01800060