ASSOCIATIONS WITH RECURRENCE OF MACULAR EDEMA IN BRANCH RETINAL VEIN OCCLUSION AFTER THE DISCONTINUATION OF ANTI VASCULAR ENDOTHELIAL GROWTH FACTOR

• Published in: Retina (Philadelphia, Pa.) Vol. 41; no. 9; p. 1892
• Main Authors: Lee, Geun Woo, Kang, Se Woong, Kang, Min Chae, Kim, Sang Jin, Kim, Yoon Young
• Format: Journal Article
• Language: English
• Published: United States 01.09.2021
• Subjects: Aged; Angiogenesis Inhibitors - administration & dosage; Bevacizumab - administration & dosage; Case-Control Studies; Female; Follow-Up Studies; Humans; Intravitreal Injections; Macula Lutea - diagnostic imaging; Macular Edema - diagnosis; Macular Edema - drug therapy; Macular Edema - etiology; Male; Middle Aged; Recurrence; Retinal Vein Occlusion - complications; Retinal Vein Occlusion - diagnosis; Retrospective Studies; Tomography, Optical Coherence - methods; Treatment Outcome; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Visual Acuity; Withholding Treatment
• ISSN: 1539-2864
• DOI: 10.1097/IAE.0000000000003118

To identify factors predicting the recurrence of macular edema after the discontinuation of intravitreal antivascular endothelial growth factor injection in patients with branch retinal vein occlusion. This retrospective study included only subjects who had discontinued injections at 3 months after the final bevacizumab injection due to fully resolved macular edema. Fifty-two eyes meeting the criteria were included in the study and divided into two groups (recurrence and no recurrence). Clinical features and measurements of retinal thickness at the time of the diagnosis and when the decision to stop injections was made (stopping point) were analyzed. At the stopping point, the no recurrence group showed a thinner parafoveal inner retina, better best-corrected visual acuity, and lower incidence of ellipsoid zone disruption in multivariate logistic regression analysis (all P < 0.05). Similarly, parafoveal inner retinal thinning of more than 30 µm, when compared with the corresponding region of the fellow eye or the unaffected region of the affected eye, was significantly related to less recurrence of macular edema. Thinning of the parafoveal inner retina as well as better vision and intact outer retinal layers are associated with a lack of recurrence of macular edema. These findings suggest that inner retinal atrophy after branch retinal vein occlusion may result in a reduction in oxygen demand in the affected retinal tissue and less production of vascular endothelial growth factor.