Endoscopic Sinus Surgery in Frontal Sinus Inverted Papilloma: A Systematic Review

• Published in: Journal of personalized medicine Vol. 15; no. 5; p. 183
• Main Authors: Fieux, Maxime, Favier, Valentin, Sousa Machado, Andre, Nourredine, Mikail, Giroudon, Caroline, Carsuzaa, Florent, Naik, Paresh P.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.05.2025; MDPI
• Subjects: Classification; Clinical trials; Endoscopy; Medical Subject Headings-MeSH; Meta-analysis; Otolaryngology; Papilloma; Quality of life; Sinuses; Software; Statistical analysis; Surgery; Systematic Review; Tumors; France; recurrence; endoscopic sinus surgery; frontal sinus; inverted papilloma; sinus surgery
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm15050183

Background: Frontal sinus inverted papilloma (IP) is a particularly rare form of IP and its management is challenging, with a high rate of recurrence. Objectives: Our aim was to evaluate the recurrence rate of frontal sinus IP after surgery and compare this rate according to the surgical modality (purely endoscopic sinus surgery vs. a combined/open approach). Design: A systematic review without meta-analysis conducted by a working group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (yo-IFOS). Data Sources and Methods: A systematic analysis of the literature was performed and reported following the criteria laid down in the SWiM guidelines. The review was registered on Prospero, a dedicated software was used for screening (Covidence), and R (v.4.2.2) was used for statistical analysis. Eligible articles were studies reporting at least five cases of frontal sinus IP surgically treated. Results: A total of 2925 studies were identified based on the MeSH equation, and 39 studies were included (n = 642 patients). Among the studies included, the recurrence rate was 18.4% (118/642) with a mean time to recurrence of 25.6 (±11.7) months. The difference between surgical modalities was not statistically significant in terms of recurrence rate (14.7% vs. 16.5%; p = 0.675). Conclusions: The recurrence rate of frontal sinus IP is not different between surgical modalities. However, it does not reduce the need for a tailored therapeutic strategy, as other factors also need to be considered (time to recurrence, complications, quality of life) when choosing the most appropriate approach.