Multiple implantation of normal amnion into cattle with generalized glycogenosis type II

• Published in: Journal of inherited metabolic disease Vol. 10; no. 1; p. 3
• Main Authors: Howell, J M, Dorling, P R, Dimarco, P N, Taylor, E G
• Format: Journal Article
• Language: English
• Published: United States 01.03.1987
• Subjects: alpha-Glucosidases - analysis; Amnion - cytology; Amnion - transplantation; Animals; Cattle; Cattle Diseases - pathology; Cattle Diseases - therapy; Disease Models, Animal; Female; Glycogen Storage Disease - veterinary; Glycogen Storage Disease Type II - pathology; Glycogen Storage Disease Type II - therapy; Glycogen Storage Disease Type II - veterinary; Male; Muscles - pathology
• ISSN: 0141-8955
• DOI: 10.1007/BF01799481

One normal and two carrier calves, and two calves affected by generalized glycogenosis type II were given multiple transplants of normal bovine amnion inserted below the external oblique abdominal muscle in the flank. The interval between transplants was approximately 5 months. The amniotic tissue was not acutely rejected but a host versus graft reaction did occur. The level of acid alpha-glucosidase activity in the amniotic tissue fell rapidly but was still present 2 months after transplantation. Enzyme levels in blood or other tissues did not rise. Excess glycogen deposition and muscle damage occurred in the affected calves and appeared to progress at a rate similar to that in untreated affected animals. One of the affected animals died aged 16 months, which was the same age as the longest surviving non-treated animal in our herd. The other treated animal died aged 24 months.