Monocyte ferritin in idiopathic haemochromatosis, thalassaemia and liver disease

Monocyte ferritin (MF) content was measured in normal subjects and patients with a variety of disorders of iron storage. MF was above the normal range in 4 patients with idiopathic haemochromatosis (IHC). However, in 4 patients with transfusion siderosis (TS), secondary to aplastic anaemia, who had...

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Bibliographic Details
Published inScandinavian journal of haematology Vol. 36; no. 1; p. 65
Main Authors Saab, G, Green, R, Jurjus, A, Sarrou, E
Format Journal Article
LanguageEnglish
Published Denmark 01.01.1986
Subjects
Acute Disease
Female
Ferritins - blood
Hemochromatosis - blood
Hepatitis - blood
Humans
Liver Diseases - blood
Male
Monocytes - metabolism
Reference Values
Siderosis - blood
Siderosis - etiology
Thalassemia - blood
Transfusion Reaction
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Summary:Monocyte ferritin (MF) content was measured in normal subjects and patients with a variety of disorders of iron storage. MF was above the normal range in 4 patients with idiopathic haemochromatosis (IHC). However, in 4 patients with transfusion siderosis (TS), secondary to aplastic anaemia, who had similar elevations in serum ferritin, MF was highly elevated. 10 patients with thalassaemia intermedia and thalassaemia major with no previous history of transfusions, but with elevated serum ferritin, also had significantly elevated MF. Disproportionately low MF in IHC could reflect defective ferritin metabolism in reticuloendothelial cells in this disorder. Finally, in 3 patients with acute rises in serum ferritin caused by acute hepatitis, MF was not increased. This suggests that MF is not directly affected by high circulating levels of serum ferritin raised acutely, but rather reflects iron storage status in conditions not associated with primary disorders of iron metabolism.
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1986.tb02652.x