Immunotropic Properties of Immobilized Interferon-α2b

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 5; pp. 693 - 697
• Main Authors: Sherstoboev, E. Yu, Shitikova, O. G., Masnaya, N. V., Danilets, M. G., Trofimova, E. S., Ligacheva, A. A., Madonov, P. G., Kinsht, D. N., Ershov, K. I., Shilova, M. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2016
• Subjects: Adjuvants, Immunologic - administration & dosage; Animals; Antigen Presentation - drug effects; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cells, Cultured; Drug Carriers - administration & dosage; Drug Evaluation, Preclinical; Immunity, Cellular - drug effects; Immunity, Humoral - drug effects; Interferon-alpha - administration & dosage; Internal Medicine; Laboratory Medicine; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - immunology; Male; Mice, Inbred CBA; Microbiology and Immunology; Neutrophils - drug effects; Neutrophils - immunology; Pathology; Phagocytosis - drug effects; Polyethylene Glycols - administration & dosage; Spleen - drug effects; Staphylococcus aureus - immunology; phagocytosis; cytokines; interferon-α2b; pegylation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3487-y

Course treatment with IFN-α2b immobilized on polyethylene glycol stimulates phagocytic activity of peritoneal macrophages and neutrophils, enhances humoral immune response in CBA/CaLac mice, stimulates IL-4 synthesis, and suppresses IFN-γ production by mitogenstimulated splenocytes from experimental animals.