A New Random Positioning Machine Modification Applied for Microgravity Simulation in Laboratory Experiments with Rats

The study presents a newly constructed modification of a random positioning machine (RPM) used in 3D-clinostat and in random mode. The main purpose is to provide an RPM animal model that uses up to four experimental animals simultaneously. In order to validate our RPM, the gravity dispersion and its...

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Bibliographic Details
Published inInventions (Basel) Vol. 7; no. 3; p. 85
Main Authors Yotov, Viktor V., Marovska, Jivka, Turiyski, Valentin, Ivanov, Stoil I.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2022
Subjects
Animal experimentation
Animals
Astronauts
Comparative analysis
Dispersion
Experiments
Gravity
hypogravity
in vivo experiments
Laboratories
Microgravity
Physiology
Positioning devices (machinery)
random positioning machine (RPM)
rat
Velocity
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Summary:The study presents a newly constructed modification of a random positioning machine (RPM) used in 3D-clinostat and in random mode. The main purpose is to provide an RPM animal model that uses up to four experimental animals simultaneously. In order to validate our RPM, the gravity dispersion and its magnitude are compared with the ones of a traditional machine. The results showed no crucial deviations in gravity dispersion and its time-averaged value in all sets of parameters. Furthermore, a posteriori stress tests are conducted on three Wistar male rats groups in order to estimate the level of stress from the setup. The social trait results suggest that the group exposed to our device has no increase in anxiety.
ISSN:2411-5134
2411-5134
DOI:10.3390/inventions7030085