Understanding and Targeting the Colon Cancer Pathogenesis: A Molecular Perspective

Abstract Colorectal cancer (CRC) one of the leading cause of cancer-related deaths worldwide. With the presently available knowledge on CRC, it is understood that the underlying is a complex process. The complexity of CRC lies in aberrant activation of several cellular signaling pathways that lead t...

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Bibliographic Details
Published inBrazilian Journal of Pharmaceutical Sciences Vol. 58
Main Author Khan, Imran
Format Journal Article
LanguageEnglish
Published Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 01.01.2022
Universidade de São Paulo
Subjects
Colon cancer
Hedgehog
Molecular targets
Notch
PHARMACOLOGY & PHARMACY
WNT/β-catenin
Molecular targets
WNT/β-catenin
Hedgehog
Colon cancer
Notch
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Summary:Abstract Colorectal cancer (CRC) one of the leading cause of cancer-related deaths worldwide. With the presently available knowledge on CRC, it is understood that the underlying is a complex process. The complexity of CRC lies in aberrant activation of several cellular signaling pathways that lead to activation and progression of CRC. In this context, recent studies have pointed towards the role of developmental pathways like; hedgehog (HH), wingless-related integration site (WNT/β-catenin) and Notch pathways that play a crucial role in maintenance and homeostasis of colon epithelium. Moreover, the deregulation of these signaling pathways has also been associated with the pathogenesis of CRC. Therefore, in the search for better therapeutic options, these pathways have emerged as potential targets. The present review attempts to highlight the role of HH, WNT/β-catenin and Notch pathways in colon carcinogenesis.
ISSN:2175-9790
2175-9790
DOI:10.1590/s2175-97902022e20354