Complex architecture of cardiac muscle thick filaments revealed

Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for u...

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Published inTrends in pharmacological sciences (Regular ed.) Vol. 45; no. 3; pp. 191 - 192
Main Authors Luther, Pradeep K., Marston, Steve B.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2024
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Abstract Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects. Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.
AbstractList Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.
Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects. Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.
Author Luther, Pradeep K.
Marston, Steve B.
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  surname: Luther
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  organization: Cardiac Function Section, NHLI, Imperial College London, Hammersmith Campus, ICTEM Building, Du Cane Road, London, W12 0NN, UK
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  surname: Marston
  fullname: Marston, Steve B.
  organization: Cardiac Function Section, NHLI, Imperial College London, Hammersmith Campus, ICTEM Building, Du Cane Road, London, W12 0NN, UK
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Cites_doi 10.1016/j.jacc.2022.10.020
10.1038/s41586-023-06691-4
10.1126/sciadv.abo7622
10.1016/j.jbc.2021.101157
10.1038/s41586-023-06690-5
10.1007/s10974-023-09647-3
10.1007/s10974-019-09567-1
10.1007/s10974-023-09646-4
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hypertrophic cardiomyopathy
thick filament structure
cryo-EM
myosin binding protein C
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Maron (bb0050) 2023; 81
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Nag (bb0020) 2023; 9
Dutta (bb0005) 2023; 623
Huang (bb0040) 2023; 44
Chu (bb0030) 2021; 297
Lee (bb0025) 2018; 115
Tamborrini (bb0010) 2023; 623
Auguin (bb0045) 2023
Auguin (10.1016/j.tips.2024.01.006_bb0045) 2023
Heling (10.1016/j.tips.2024.01.006_bb0015) 2020; 41
Lee (10.1016/j.tips.2024.01.006_bb0025) 2018; 115
Nag (10.1016/j.tips.2024.01.006_bb0020) 2023; 9
Maron (10.1016/j.tips.2024.01.006_bb0050) 2023; 81
Chu (10.1016/j.tips.2024.01.006_bb0030) 2021; 297
Huang (10.1016/j.tips.2024.01.006_bb0040) 2023; 44
Dutta (10.1016/j.tips.2024.01.006_bb0005) 2023; 623
Tamborrini (10.1016/j.tips.2024.01.006_bb0010) 2023; 623
Taylor (10.1016/j.tips.2024.01.006_bb0035) 2023; 44
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SubjectTerms cryo-EM
hypertrophic cardiomyopathy
myosin binding protein C
thick filament structure
titin
Title Complex architecture of cardiac muscle thick filaments revealed
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