Complex architecture of cardiac muscle thick filaments revealed

• Published in: Trends in pharmacological sciences (Regular ed.) Vol. 45; no. 3; pp. 191 - 192
• Main Authors: Luther, Pradeep K., Marston, Steve B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2024
• Subjects: cryo-EM; hypertrophic cardiomyopathy; myosin binding protein C; thick filament structure; titin; titin; hypertrophic cardiomyopathy; thick filament structure; cryo-EM; myosin binding protein C
• ISSN: 0165-6147; 1873-3735
• DOI: 10.1016/j.tips.2024.01.006

Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects. Muscle contraction is orchestrated by the well-understood thin filaments and the markedly complex thick filaments. Studies by Dutta et al. and Tamborrini et al., discussed here, have unravelled the structure of the mammalian heart thick filament in exquisite near-atomic detail and pave the way for understanding physiological modulation pathways and mutation-induced dysfunction and for designing potential drugs to modify defects.