Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice

Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner. Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans (1 mg/kg and 1.3...

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Bibliographic Details
Published inPlanta medica Vol. 67; no. 2; p. 176
Main Authors Bajad, S, Bedi, K L, Singla, A K, Johri, R K
Format Journal Article
LanguageEnglish
Published Germany 01.03.2001
Subjects
Alkaloids
Animals
Benzodioxoles
Digestive System - drug effects
Dose-Response Relationship, Drug
Gastric Emptying - drug effects
Male
Mice
Molecular Structure
Piperidines - toxicity
Plant Extracts - toxicity
Plants, Medicinal - chemistry
Polyunsaturated Alkamides
Rats
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Summary:Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner. Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans (1 mg/kg and 1.3 mg/kg p.o. in rats and mice, respectively). However, at the same dose the effect was insignificant for GE of liquids. One week oral treatment of 1 mg/kg and 1.3 mg/kg in rats and mice, respectively, did not produce a significant change in activity as compared to single dose administration. GE inhibitory activity of 1 is independent of gastric acid and pepsin secretion.
ISSN:0032-0943
DOI:10.1055/s-2001-11505