Antidiarrhoeal activity of piperine in mice

Peppers are common food ingredients used worldwide. They are also added in traditional antidiarrhoeal formulations of different herbs. Piperine (1) is an alkaloidal constituent of black and long peppers recently established as a bioavailability enhancer of drugs and other substances. As a part of ef...

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Bibliographic Details
Published inPlanta medica Vol. 67; no. 3; p. 284
Main Authors Bajad, S, Bedi, K L, Singla, A K, Johri, R K
Format Journal Article
LanguageEnglish
Published Germany 01.04.2001
Subjects
Alkaloids
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antidiarrheals - therapeutic use
Benzodioxoles
Cathartics
Diarrhea - chemically induced
Diarrhea - drug therapy
Digestive System
Male
Mice
Phytotherapy
Piperidines - therapeutic use
Plant Extracts - therapeutic use
Polyunsaturated Alkamides
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Summary:Peppers are common food ingredients used worldwide. They are also added in traditional antidiarrhoeal formulations of different herbs. Piperine (1) is an alkaloidal constituent of black and long peppers recently established as a bioavailability enhancer of drugs and other substances. As a part of efforts to study its effects on the gastrointestinal tract, the experiments were performed to determine the rationale, if any, for its use in traditional antidiarrhoeal formulations. Antidiarrhoeal activity of 1 against castor oil, MgSO4 and arachidonic acid was studied in mice. It significantly inhibited diarrhoea produced by these cathartics at 8 and 32 mg/kg p.o. dose. Inhibition of castor oil induced enteropooling by 1 suggests its inhibitory effect on prostaglandins. The results validate the rationale for its use in traditional antidiarrhoeal formulations.
ISSN:0032-0943
DOI:10.1055/s-2001-11999