Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics

The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed...

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Published inChemical communications (Cambridge, England) Vol. 54; no. 6; pp. 611 - 614
Main Authors Wenzel, Margot N, Meier-Menches, Samuel M, Williams, Thomas L, Rämisch, Eberard, Barone, Giampaolo, Casini, Angela
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 2018
Subjects
Adducts
Coordination compounds
Fingers
Mass spectrometry
Organometallic compounds
Quantum mechanics
Zinc
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Summary:The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc08406d