B Cell Liaison Confounds HIV-1 Evolution

B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one “helper” B cell lineage...

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Bibliographic Details
Published inCell Vol. 158; no. 3; pp. 475 - 476
Main Author McHeyzer-Williams, Michael G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 31.07.2014
Subjects
AIDS Vaccines - chemistry
AIDS Vaccines - immunology
Antibodies, Neutralizing - immunology
HIV Antibodies - immunology
HIV-1 - physiology
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Summary:B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one “helper” B cell lineage selects variants that drive a separate B cell lineage toward broad neutralization. B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one “helper” B cell lineage selects variants that drive a separate B cell lineage toward broad neutralization.
Bibliography:ObjectType-Article-2
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2014.07.018