B Cell Liaison Confounds HIV-1 Evolution
B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one “helper” B cell lineage...
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Published in | Cell Vol. 158; no. 3; pp. 475 - 476 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
31.07.2014
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Subjects | |
Online Access | Get full text |
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Summary: | B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one “helper” B cell lineage selects variants that drive a separate B cell lineage toward broad neutralization.
B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one “helper” B cell lineage selects variants that drive a separate B cell lineage toward broad neutralization. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 |
ISSN: | 0092-8674 1097-4172 |
DOI: | 10.1016/j.cell.2014.07.018 |