Head and neck cancer patient-derived xenograft models – A systematic review
[Display omitted] •This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational...
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Published in | Critical reviews in oncology/hematology Vol. 155; p. 103087 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.11.2020
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Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational research for the HNC.
Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.
An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively.
63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified.
HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC. |
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Bibliography: | SourceType-Scholarly Journals-1 ObjectType-Feature-4 ObjectType-Undefined-1 content type line 23 ObjectType-Review-2 ObjectType-Article-3 |
ISSN: | 1040-8428 1879-0461 |
DOI: | 10.1016/j.critrevonc.2020.103087 |