Integrated single-cell transcriptome and T cell receptor profiling reveals defects of T cell exhaustion in pulmonary tuberculosis

• Published in: The Journal of infection Vol. 88; no. 6; p. 106158
• Main Authors: Wen, Zilu, Wang, Lin, Ma, Hui, Li, Leilei, Wan, Laiyi, Shi, Lei, Li, Hongwei, Chen, Hui, Hao, Wentao, Song, Shu, Xue, Qinghua, Wei, Yutong, Li, Feng, Xu, Jianqing, Zhang, Shulin, Wong, Ka-Wing, Song, Yanzheng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2024
• Subjects: Chronic inflammation; Immunotherapy; Single-cell RNA sequencing; T cell exhaustion; Tuberculosis; T cell exhaustion; Tuberculosis; Chronic inflammation; Single-cell RNA sequencing; Immunotherapy

Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated in chronic inflammatory diseases, remains unexplored in tuberculosis. Given that immunotherapy targe...