The use of acetylation to improve the performance of hyaluronic acid-based dermal filler

Injectable dermal fillers, which are used for various plastic surgery purposes, are experiencing explosive market growth due to increasing interest in appearance management. Hyaluronic acid (HA) hydrogels have been considered an ideal material for fillers due to their high-water retention, biodegrad...

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Bibliographic Details
Published inThe Korean journal of chemical engineering Vol. 40; no. 8; pp. 1963 - 1969
Main Authors Gwak, So-Jung, Lee, Yu Bin, Lee, Eun Joo, Park, Kyoung Hwan, Kang, Sun-Woong, Huh, Kang Moo
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2023
Springer Nature B.V
한국화학공학회
Subjects
Acetylation
Biocompatibility
Biomedical materials
Biotechnology
Catalysis
Chemistry
Chemistry and Materials Science
Fillers
Hyaluronic acid
Hydrogels
Industrial Chemistry/Chemical Engineering
Materials Science
Performance enhancement
Physical properties
Plastic surgery
Tissue engineering
화학공학
Hyaluronic Acid
Enzyme Resistance
Acetylation
Mechanical Property
Filler
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ISSN0256-1115
1975-7220
DOI10.1007/s11814-023-1496-x

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Summary:Injectable dermal fillers, which are used for various plastic surgery purposes, are experiencing explosive market growth due to increasing interest in appearance management. Hyaluronic acid (HA) hydrogels have been considered an ideal material for fillers due to their high-water retention, biodegradability, and biocompatibility. However, their application is limited by shortcomings in durability and persistence caused by rapid enzymatic degradation. Therefore, in this study, we introduce acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) hydrogels for a novel approach for improving the physical properties and gel retention time of HA. The AcHA-DVS hydrogels showed significant advantages in terms of longevity and performance as dermal fillers compared to HA-DVS hydrogels. These results suggest that our new AcHA-DVS hydrogel is a promising biomaterial as an injectable filler or scaffold for tissue engineering.
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ISSN:0256-1115
1975-7220
DOI:10.1007/s11814-023-1496-x