Actionable Genotypes and Their Association with Life Span in Iceland

• Published in: The New England journal of medicine Vol. 389; no. 19; pp. 1741 - 1752
• Main Authors: Jensson, Brynjar O., Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Helgason, Hannes, Oddsson, Asmundur, Sveinbjornsson, Gardar, Eggertsson, Hannes P., Halldorsson, Gisli H., Atlason, Bjarni A., Jonsson, Hakon, Oskarsson, Gudjon R., Sturluson, Arni, Gudjonsson, Sigurjon A., Thorisson, Gudmundur A., Zink, Florian, Moore, Kristjan H.S., Palsson, Gunnar, Sigurdsson, Asgeir, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Magnusson, Magnus K., Helgadottir, Anna, Steinthorsdottir, Valgerdur, Gudmundsson, Julius, Stacey, Simon N., Hilmarsson, Rafn, Olafsson, Isleifur, Johannsson, Oskar T., Arnar, David O., Saemundsdottir, Jona, Magnusson, Olafur T., Masson, Gisli, Halldorsson, Bjarni V., Helgason, Agnar, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Stefansson, Kari, Sulem, Patrick
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 09.11.2023
• Subjects: Aging; Aging General; Alleles; Alternative splicing; Breast Cancer; Cancer; Cardiology; Cardiology General; Cardiovascular diseases; Cardiovascular Diseases - genetics; Confidence intervals; Disease; Disease - genetics; Gastrointestinal Tract Cancer; Genes; Genetic Testing; Genetic Variation; Genetics; Genetics General; Genomes; Genomics; Genotype; Genotype & phenotype; Genotypes; Geriatrics; Gynecologic Oncology; Hematology; Humans; Iceland - epidemiology; Life span; Longevity - genetics; Neoplasms - genetics; Oncology; Oncology General; Pathogenicity; Regression analysis; Survival; Survival analysis; Iceland
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2300792

This study examines the relationship of pathogenic and likely pathogenic variants for which preventive or therapeutic measures are available to life span and specific causes of death.