Anti-ulcer activity of ethanol extract of Terminalia pallida Brandis. in Swiss albino rats

• Published in: Journal of ethnopharmacology Vol. 97; no. 2; pp. 405 - 408
• Main Authors: Gupta, M., Mazumder, U.K., Manikandan, L., Bhattacharya, S., Senthilkumar, G.P., Suresh, R.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 28.02.2005; Elsevier
• Subjects: Anti-ulcer; anti-ulcer activity; Antioxidant; Biological and medical sciences; fruit extracts; General pharmacology; Lipid peroxidation; Medical sciences; medicinal plants; peptic ulcers; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; rats; stomach ulcers; Terminalia; Terminalia pallida; Terminalia pallida Brandis; traditional medicine; India; Terminalia pallida Brandis; Lipid peroxidation; Antioxidant; Anti-ulcer; Ethanol; Rat; Pharmacognosy; Rodentia; Lipids; Antiulcer agent; Extract; Medicinal plant; Vertebrata; Mammalia; Animal; Plant origin; Peroxidation
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2004.10.017

Ethanol extract of Terminalia pallida Brandis. (EETP) was evaluated for its anti-ulcer activity against various models of ulcers, such as drug-induced ulcers, histamine-induced ulcers and ethanol-induced ulcers in Swiss albino rats. The EETP at the doses of 250 and 500 mg/kg per os (p.o.) exhibited significant protection against ulcers produced by indomethacin, histamine and the effect was comparable to that of the reference drug famotidine (30 mg/kg b.w) orally. The extract also afforded significant protection against ethanol-induced gastric ulceration. Meanwhile, EETP significantly lowered the elevated lipid peroxide level (thiobarbituric acid reactive substances (TBARS)) and restored the altered glutathione level in ethanol-induced gastric ulceration. The present investigation revealed that the EETP exhibited significant anti-ulcer activity by enhancing antioxidant potential of the gastric mucosa, thereby reducing mucosal damage.