Aspirin-Exacerbated Respiratory Disease

About 7% of patients with asthma have mucosal swelling, nasal polyps, and worsening of asthma in response to aspirin and other COX-1 inhibitors. Symptoms may be managed with glucocorticoids, antihistamines, and aspirin desensitization.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 379; no. 11; pp. 1060 - 1070
Main Authors White, Andrew A, Stevenson, Donald D
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 13.09.2018
Subjects
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Antihistamines
Aspirin
Aspirin - adverse effects
Aspirin - immunology
Asthma
Asthma, Aspirin-Induced - diagnosis
Asthma, Aspirin-Induced - drug therapy
Cyclooxygenase 1
Cyclooxygenase Inhibitors - adverse effects
Desensitization, Immunologic
Drug dosages
Enzymes
Glucocorticoids
Glucocorticoids - therapeutic use
Humans
Mucosa
Nasal Polyps - chemically induced
Nasal Polyps - surgery
Nonsteroidal anti-inflammatory drugs
Pain
Patients
Polyps
Respiratory diseases
Sinuses
Surgery
Viral infections
United States > US
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Summary:About 7% of patients with asthma have mucosal swelling, nasal polyps, and worsening of asthma in response to aspirin and other COX-1 inhibitors. Symptoms may be managed with glucocorticoids, antihistamines, and aspirin desensitization.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra1712125