Glucocorticoid resistance and hypersensitivity

This article emphasizes the disorders caused by mutations and polymorphisms of the alpha form of the glucocorticoid receptor. These disorders usually present with increased circulating cortisol concentrations and must be distinguished from Cushing's syndrome, because the therapies are markedly...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 34; no. 2; p. 315
Main Authors Malchoff, Carl D, Malchoff, Diana M
Format Journal Article
LanguageEnglish
Published United States 01.06.2005
Subjects
Adrenocortical Hyperfunction - genetics
Adrenocortical Hyperfunction - metabolism
Adrenocortical Hyperfunction - physiopathology
Animals
Glucocorticoids - physiology
Humans
Pituitary ACTH Hypersecretion - genetics
Pituitary ACTH Hypersecretion - metabolism
Pituitary ACTH Hypersecretion - physiopathology
Receptors, Glucocorticoid - genetics
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Summary:This article emphasizes the disorders caused by mutations and polymorphisms of the alpha form of the glucocorticoid receptor. These disorders usually present with increased circulating cortisol concentrations and must be distinguished from Cushing's syndrome, because the therapies are markedly different. The other disorders present with clinical features limited to a specific organ system. Although they illustrate important physiologic and pathophysiologic principles, they usually are not confused with Cushing's syndrome.
ISSN:0889-8529
DOI:10.1016/j.ecl.2005.02.002