Human alveolar macrophages express Ia-like antigens

Monoclonal antibody to la-like antigens was used to demonstrate the presence of these antigens on human alveolar macrophages. Immunoprecipitation demonstrated the 27,000 and 34,000 molecular weight peaks that correspond to the la-like antigen subunits. Immunofluorescence confirmed the presence of la...

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Bibliographic Details
Published inBlood Vol. 58; no. 5; pp. 1040 - 1042
Main Authors Hocking, W, Billing, R, Foon, K, Golde, D
Format Journal Article
LanguageEnglish
Published United States 01.11.1981
Subjects
Antibodies, Monoclonal
Cell Communication
Chemical Precipitation
Fluorescent Antibody Technique
Histocompatibility Antigens Class II
Humans
Macrophages - immunology
Pulmonary Alveoli - cytology
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Summary:Monoclonal antibody to la-like antigens was used to demonstrate the presence of these antigens on human alveolar macrophages. Immunoprecipitation demonstrated the 27,000 and 34,000 molecular weight peaks that correspond to the la-like antigen subunits. Immunofluorescence confirmed the presence of la-like antigens on alveolar macrophages but not on other bronchoalveolar cells. The presence of alveolar macrophage la-like antigens may be important in cellular interactions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-4971
1528-0020
DOI:10.1182/blood.v58.5.1040.1040