Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study
Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n =...
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| Published in | Clinical hemorheology and microcirculation Vol. 64; no. 3; pp. 297 - 304 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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London, England
SAGE Publications
01.01.2016
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| Abstract | Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography.
The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line.
VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%. |
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| AbstractList | Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography.The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line.VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%. Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography. The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line. VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%. |
| Author | Mrowietz, C. Spitzer, S.G. Jung, F. Gerk, U. Franke, R.P. Sternitzky, R. |
| Author_xml | – sequence: 1 givenname: U. surname: Gerk fullname: Gerk, U. organization: , Helmholtz-Zentrum Geesthacht, Teltow – sequence: 2 givenname: C. surname: Mrowietz fullname: Mrowietz, C. organization: , Helmholtz-Zentrum Geesthacht, Teltow – sequence: 3 givenname: R. surname: Sternitzky fullname: Sternitzky, R. organization: , Helmholtz-Zentrum Geesthacht, Teltow – sequence: 4 givenname: R.P. surname: Franke fullname: Franke, R.P. organization: , Helmholtz-Zentrum Geesthacht, Teltow – sequence: 5 givenname: S.G. surname: Spitzer fullname: Spitzer, S.G. organization: , Helmholtz-Zentrum Geesthacht, Teltow – sequence: 6 givenname: F. surname: Jung fullname: Jung, F. email: friedrich.jung@hzg.de organization: , Helmholtz-Zentrum Geesthacht, Teltow |
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| Cites_doi | 10.1016/0720-048X(94)90092-2 10.1515/bmte.1997.42.6.168 10.1002/ajh.1171 10.1097/00004424-196909000-00007 10.1007/BF01726918 10.1038/ki.1996.181 10.1080/02841850801885978 10.1016/j.mvr.2008.05.002 10.1007/s00330-005-0081-5 10.1038/ki.1985.32 10.1097/00004424-199109000-00006 10.1515/bmte.1990.35.9.195 10.3233/CH-162045 10.3233/CH-162058 10.1002/jmri.23511 10.1097/00005344-198500073-00007 10.1007/BF00179994 10.1097/00004424-199328090-00010 10.3109/00365518109097426 10.1016/0720-048X(94)00579-2 10.1097/01.RLI.0000066249.29279.1e 10.1378/chest.116.4.1039 10.1006/mvre.2000.2268 10.1016/j.tiv.2006.09.018 10.1097/00004424-199311000-00012 |
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| Keywords | coronary artery disease Cutaneous microcirculation Ioxaglate |
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(Berl) doi: 10.1515/bmte.1997.42.6.168 contributor: fullname: Klyscz – volume: 68 start-page: 149 year: 2001 ident: 10.3233/CH-168101_ref25 article-title: Comparison of the effects of radiographic contrast media on dehydration and filterability of red blood cells from donors homozygous for hemoglobin A or hemoglobin S publication-title: Am J Hematol doi: 10.1002/ajh.1171 contributor: fullname: Losco – volume: 4 start-page: 327 year: 1969 ident: 10.3233/CH-168101_ref32 article-title: Does renal blood flow rise or fall in response to diatrizoate publication-title: Invest Radiol doi: 10.1097/00004424-196909000-00007 contributor: fullname: Sherwood – volume: 233 start-page: H318 year: 1977 ident: 10.3233/CH-168101_ref13 article-title: A microscope television system for studying flow velocity in human skin capillaries publication-title: Am J Physiol contributor: fullname: Fagrell – volume: 64 start-page: 653 year: 1986 ident: 10.3233/CH-168101_ref21 article-title: Predictor function of hemorheologic parameters with reference to the incidence of manifest circulatory disorders: Concept of the Aachen study publication-title: Klin Wochenschr doi: 10.1007/BF01726918 contributor: fullname: Kiesewetter – volume: 49 start-page: 1268 year: 1996 ident: 10.3233/CH-168101_ref24 article-title: Effects of contrast media and mannitol on renal medullary blood flow and red cell aggregation in the rat kidney publication-title: Kidney Int doi: 10.1038/ki.1996.181 contributor: fullname: Liss – volume: 49 start-page: 337 year: 2008 ident: 10.3233/CH-168101_ref20 article-title: Iodinated contrast media: Effect of osmolarity and injection temperature on erythrocyte morphology in vitro publication-title: Acta Radiol doi: 10.1080/02841850801885978 contributor: fullname: Kerl – volume: 76 start-page: 110 year: 2008 ident: 10.3233/CH-168101_ref14 article-title: Influence of various radiographic contrast media on the buckling of endothelial cells publication-title: Microvasc Res doi: 10.1016/j.mvr.2008.05.002 contributor: fullname: Franke – volume: 16 start-page: 1041 year: 2006 ident: 10.3233/CH-168101_ref4 article-title: Members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR). Effects of iodinated contrast media on blood and endothelium publication-title: Eur Radiol doi: 10.1007/s00330-005-0081-5 contributor: fullname: Aspelin – volume: 409 start-page: 1 year: 1997 ident: 10.3233/CH-168101_ref23 article-title: Effects of contrast media on renal microcirculation and oxygen tension. An experimental study in the rat publication-title: Acta Radiol Suppl contributor: fullname: Liss – volume: 27 start-page: 465 year: 1985 ident: 10.3233/CH-168101_ref8 article-title: A role for calcium in radiocontrast-induced reductions in renal hemodynamics publication-title: Kidney Int doi: 10.1038/ki.1985.32 contributor: fullname: Bakris – volume: 26 start-page: 810 year: 1991 ident: 10.3233/CH-168101_ref16 article-title: The effect of low-osmolar ionic and non-ionic contrast media on human blood viscosity, erythrocyte morphology, and aggregation behavior publication-title: Investigative Radiology doi: 10.1097/00004424-199109000-00006 contributor: fullname: Hardeman – volume: 35 start-page: 195 year: 1990 ident: 10.3233/CH-168101_ref19 article-title: Fehleranalyse, biologische Einfluß-faktoren und Varianz der periungualen Videokapillarmikroskopie publication-title: Biomed Technik doi: 10.1515/bmte.1990.35.9.195 contributor: fullname: Jung – volume: 64 start-page: 65 issue: 1 year: 2016 ident: 10.3233/CH-168101_ref30 article-title: The responses of glabrous and nonglabrous skin microcirculation to graded dynamic exercise and its recovery publication-title: Clin Hemorheol Microcirc doi: 10.3233/CH-162045 contributor: fullname: Potočnik – ident: 10.3233/CH-168101_ref1 doi: 10.3233/CH-162058 – volume: 35 start-page: 1139 issue: 5 year: 2012 ident: 10.3233/CH-168101_ref35 article-title: Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion-weighted MRI publication-title: J Magn Reson Imaging doi: 10.1002/jmri.23511 contributor: fullname: Wang – volume: 7 start-page: 53 year: 1985 ident: 10.3233/CH-168101_ref11 article-title: Dynamics of microcirculation in humans publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-198500073-00007 contributor: fullname: Fagrell – volume: 71 start-page: 132 year: 1993 ident: 10.3233/CH-168101_ref17 article-title: Primary and secondary microcirculatory disorders in essential hypertension publication-title: Clin Investig doi: 10.1007/BF00179994 contributor: fullname: Jung – ident: 10.3233/CH-168101_ref12 – volume: 28 start-page: 814 year: 1993 ident: 10.3233/CH-168101_ref34 article-title: Modulation of the renal effects of contrast media by endothelium-derived nitric oxide in the rat publication-title: Invest Radiol doi: 10.1097/00004424-199328090-00010 contributor: fullname: Touati – volume: 41 start-page: 27 year: 1981 ident: 10.3233/CH-168101_ref26 article-title: Morphological determinants of red cell deformability publication-title: J Clin Lab Invest doi: 10.3109/00365518109097426 contributor: fullname: Meiselman – volume: 34 start-page: 311 issue: 3 year: 2015 ident: 10.3233/CH-168101_ref27 article-title: The action of stress hormones on the structure and function of erythrocyte membrane publication-title: Gen Physiol Biophys contributor: fullname: Mokrushnikov – volume: 19 start-page: 91 year: 1995 ident: 10.3233/CH-168101_ref29 article-title: The acute effect of ioversol on kidney function: Role of endothelin publication-title: Eur J Radiol doi: 10.1016/0720-048X(94)00579-2 contributor: fullname: Oldroy – volume: 38 start-page: 366 year: 2003 ident: 10.3233/CH-168101_ref33 article-title: Calcium-dependent injury of human microvascular endothelial cells induced by a variety of iodinated radiographic contrast media publication-title: Invest Radiol doi: 10.1097/01.RLI.0000066249.29279.1e contributor: fullname: Sumimura – volume: 37 start-page: 329 year: 2007 ident: 10.3233/CH-168101_ref15 article-title: The effect of radiographic contrast media on the morphology of human venous endothelial cells publication-title: Clin Hemorheol Microcirc contributor: fullname: Franke – volume: 116 start-page: 1039 issue: 4 year: 1999 ident: 10.3233/CH-168101_ref7 article-title: Effect of contrast media on coronary vascular resistance: Contrast-induced coronary vasodilation publication-title: Chest doi: 10.1378/chest.116.4.1039 contributor: fullname: Baile – volume: 60 start-page: 193 year: 2000 ident: 10.3233/CH-168101_ref5 article-title: Influence of a new monomeric nonionic radiographic contrast medium (Iobitridol-350 versus NaCl) on cutaneous microcirculation: Single-center, prospective, randomized, double-blind phase IV study in parallel group design publication-title: Microvasc Res doi: 10.1006/mvre.2000.2268 contributor: fullname: Bach – volume: 1996 start-page: 214 issue: 37 ident: 10.3233/CH-168101_ref6 article-title: Influence of a non-ionic radiography contrast medium on the microcirculation publication-title: Acta Radiol contributor: fullname: Bach – volume: 21 start-page: 191 year: 2007 ident: 10.3233/CH-168101_ref31 article-title: Effects of iodinated contrast media on endothelium: An in vitro study publication-title: Toxicol In Vitro doi: 10.1016/j.tiv.2006.09.018 contributor: fullname: Ramponi – volume: 28 start-page: 1033 year: 1993 ident: 10.3233/CH-168101_ref28 article-title: Red-cell trapping in the rat renal microcirculation induced by low-osmolar contrast media and mannitol publication-title: Invest Radiol doi: 10.1097/00004424-199311000-00012 contributor: fullname: Nygren – ident: 10.3233/CH-168101_ref9 – volume: 38 start-page: 1 year: 2008 ident: 10.3233/CH-168101_ref18 article-title: The effect of radiographic contrast media on the morphology of human erythrocytes publication-title: Clin Hemorheol Microcirc contributor: fullname: Jung |
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| Snippet | Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous... |
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| SubjectTerms | Aged Coronary Artery Disease - blood Coronary Artery Disease - drug therapy Double-Blind Method Female Humans Ioxaglic Acid - administration & dosage Ioxaglic Acid - therapeutic use Male Microcirculation - drug effects Middle Aged Prospective Studies |
| Title | Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study |
| URI | https://journals.sagepub.com/doi/full/10.3233/CH-168101 https://www.ncbi.nlm.nih.gov/pubmed/28128751 https://search.proquest.com/docview/1862767906 |
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