Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study

• Published in: Clinical hemorheology and microcirculation Vol. 64; no. 3; pp. 297 - 304
• Main Authors: Gerk, U., Mrowietz, C., Sternitzky, R., Franke, R.P., Spitzer, S.G., Jung, F.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2016
• Subjects: Aged; Coronary Artery Disease - blood; Coronary Artery Disease - drug therapy; Double-Blind Method; Female; Humans; Ioxaglic Acid - administration & dosage; Ioxaglic Acid - therapeutic use; Male; Microcirculation - drug effects; Middle Aged; Prospective Studies; coronary artery disease; Cutaneous microcirculation; Ioxaglate
• ISSN: 1386-0291; 1875-8622
• DOI: 10.3233/CH-168101

Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography. The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line. VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%.