A multicomponent two-step strategy for the synthesis of polysubstituted pyrrolo[3,2-]pyridin-4-ones using a solid acid as a recyclable catalyst

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 21; no. 11; pp. 319 - 3115
• Main Authors: Li, Chunmei, Zhang, Furen, Qi, Chenze
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 04.06.2019; Royal Society of Chemistry
• Subjects: Catalysis; Catalysts; Chemistry; Chemistry, Multidisciplinary; Crystallography; Deactivation; Green & Sustainable Science & Technology; Green chemistry; heterocyclic compounds; liquids; mixing; Physical Sciences; Purification; Recyclability; Science & Technology; Science & Technology - Other Topics; solvents; Substrates; Synthesis; DESIGN; 3-COMPONENT DOMINO REACTIONS; CARBONACEOUS MATERIAL; PYRROLOPYRIDINONES; EFFICIENT SYNTHESIS; BIOLOGICAL EVALUATION; KINASE INHIBITORS; DERIVATIVES; ACCESS; CYCLIZATION
• ISSN: 1463-9262; 1463-9270; 1463-9270
• DOI: 10.1039/c9gc01120j

A multicomponent two-step strategy for the synthesis of polysubstituted pyrrolo[3,2- c ]pyridin-4-one derivatives has been described. The reactions can be readily performed by mixing inexpensive starting materials using two-step methods under mild conditions, and the products can be easily obtained from the mother liquid without any further treatment. Moreover, the solid acid catalyst can be circulated at least 6 times without obvious deactivation. Furthermore, a mechanism for the reaction process has been proposed. Overall the bond forming efficiency, the use of green solvent as the reaction medium, recyclability of the solid acid catalyst, easy work-up/purification, and a wide substrate scope make this method highly attractive to assemble heterocyclic scaffolds. A two-step strategy for the synthesis of polysubstituted pyrrolo[3,2- c ]pyridin-4-ones using a solid acid as a recyclable catalyst.