Sustained delivery of biomolecules from gelatin carriers for applications in bone regeneration

Local delivery of therapeutic biomolecules to stimulate bone regeneration has matured considerably during the past decades, but control over the release of these biomolecules still remains a major challenge. To this end, suitable carriers that allow for tunable spatial and temporal delivery of biomo...

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Bibliographic Details
Published inTherapeutic delivery Vol. 5; no. 8; p. 943
Main Authors Song, Jiankang, Leeuwenburgh, Sander Cg
Format Journal Article
LanguageEnglish
Published England 01.08.2014
Subjects
Anti-Bacterial Agents - administration & dosage
Bone Morphogenetic Proteins - administration & dosage
Bone Regeneration
Delayed-Action Preparations
Drug Carriers
Fibroblast Growth Factor 2 - administration & dosage
Gelatin - administration & dosage
Transforming Growth Factor beta1 - administration & dosage
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ISSN2041-5990
DOI10.4155/tde.14.42

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Summary:Local delivery of therapeutic biomolecules to stimulate bone regeneration has matured considerably during the past decades, but control over the release of these biomolecules still remains a major challenge. To this end, suitable carriers that allow for tunable spatial and temporal delivery of biomolecules need to be developed. Gelatin is one of the most widely used natural polymers for the controlled and sustained delivery of biomolecules because of its biodegradability, biocompatibility, biosafety and cost-effectiveness. The current study reviews the applications of gelatin as carriers in form of bulk hydrogels, microspheres, nanospheres, colloidal gels and composites for the programmed delivery of commonly used biomolecules for applications in bone regeneration with a specific focus on the relationship between carrier properties and delivery characteristics.
ISSN:2041-5990
DOI:10.4155/tde.14.42