Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TRO...

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Published inNature human behaviour Vol. 1; no. 4; p. 0081
Main Authors Heck, Angela, Milnik, Annette, Vukojevic, Vanja, Petrovska, Jana, Egli, Tobias, Singer, Jochen, Escobar, Pablo, Sengstag, Thierry, Coynel, David, Freytag, Virginie, Fastenrath, Matthias, Demougin, Philippe, Loos, Eva, Hartmann, Francina, Schicktanz, Nathalie, Delarue Bizzini, Bernardo, Vogler, Christian, Kolassa, Iris-Tatjana, Wilker, Sarah, Elbert, Thomas, Schwede, Torsten, Beisel, Christian, Beerenwinkel, Niko, de Quervain, Dominique J.-F., Papassotiropoulos, Andreas
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2017
Nature Publishing Group
Subjects
631/208/1515
631/378/1595
631/477
Aversive
Behavioral Sciences
Biomedical and Life Sciences
Experimental Psychology
Extremes
Gene expression
Genocide
Genotype & phenotype
Life Sciences
Medical imaging
Memory
Mental disorders
Microeconomics
Neuroimaging
Neurosciences
Normal distribution
Personality and Social Psychology
Post traumatic stress disorder
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Summary:Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors. TROVE2 , a gene implicated in inflammatory response and autoimmunity, is also associated with enhanced memory for emotionally charged events in post-traumatic stress disorder.
ISSN:2397-3374
2397-3374
DOI:10.1038/s41562-017-0081