An improved screening method for 3-methoxy-4-hydroxy mandelic acid excretion in urine

A screening method is described for urinary 3-methoxy-4-hydroxy mandelic acid using an initial ion exchange procedure, vanillin formation and extraction into toluene. The technique, is simple, rapid and specific, with a reference value up to 35 mumol (7.0 mg)/day established on 92 normal human subje...

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Bibliographic Details
Published inPathology Vol. 10; no. 1; p. 53
Main Authors Rumble, B A, Dick, M
Format Journal Article
LanguageEnglish
Published England 01.01.1978
Subjects
Chromatography, Ion Exchange
Flavoring Agents - biosynthesis
Humans
Indicators and Reagents
Mandelic Acids - urine
Pheochromocytoma - diagnosis
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Summary:A screening method is described for urinary 3-methoxy-4-hydroxy mandelic acid using an initial ion exchange procedure, vanillin formation and extraction into toluene. The technique, is simple, rapid and specific, with a reference value up to 35 mumol (7.0 mg)/day established on 92 normal human subjects. Over 200 patients' urines were analysed by the method of which 18 gave values above the reference range. The majority of these increased excretions are attributed to the metabolic effects of drugs, one patient suffered from phaeochromocytoma and only 2 results remaining unexplained.
ISSN:0031-3025
DOI:10.3109/00313027809063479