Magnetic Resonance Angiography, Function and Viability Evaluation in Patients with Kawasaki Disease

• Published in: Journal of cardiovascular magnetic resonance Vol. 8; no. 3; pp. 493 - 498
• Main Authors: Mavrogeni, Sophie, Papadopoulos, George, Douskou, Marouso, Kaklis, Savas, Seimenis, Ioannis, Varlamis, George, Karanasios, Evangelos, Krikos, Xenofon, Giannoulia, Aglaia, Cokkinos, Dennis V
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2006
• Subjects: Child; Contrast Media; Coronary Aneurysm - diagnosis; Coronary Aneurysm - diagnostic imaging; Female; Gadolinium DTPA; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Male; Mucocutaneous Lymph Node Syndrome - pathology; Myocardial Infarction - diagnosis; Myocardial Infarction - diagnostic imaging; Ultrasonography
• ISSN: 1097-6647; 1532-429X
• DOI: 10.1080/10976640600604773

Objectives: We evaluated the ability of magnetic resonance imaging to perform a noninvasive assessment of coronary arteries, function and viability in one examination in a population with Kawasaki disease. Background: Magnetic resonance angiography (MRA) can identify coronary abnormalities in patients with Kawasaki disease (KD). Contrast enhanced cardiovascular magnetic resonance (CeCMR) is the current gold standard for scar detection. Steady-state, free precession (SSFP) cine is a reliable technique to evaluate myocardial function and wall motion. Methods: Twenty patients with KD aged 7-12 yrs, were examined. Coronary MRA was performed using a 1.5 T system with two ECG-triggered pulse sequences. CeCMR images were acquired 15 minutes after the IV injection of 0.1 mmol/kg Gd-DTPA using an inversion recovery sequence. SSFP cines were acquired using 6-mm short-axis slices from the atrioventricular ring to the apex. Results: Aneurysms of the coronary arteries were identified in 7 patients and coronary ectasia was present in the remaining 12 patients while 1 patient had both. Transmural anterior-apical scar was detected by ceCMR in two cases, while small inferior necrosis was identified in another 2 cases. Left ventricular function was deteriorated only in the two patients with antero-apical infarction. The presence of myocardial infarction was detected in the territory supplied by the involved coronary artery. Conclusion: In Kawasaki disease MRA, SSFP cine and ceCMR are able to perform noninvasive coronary artery evaluation, function and infarct detection in a single study.