Effect of BCG on Experimental Asbestosis

Chrysotile inoculated intratracheally into normal and BCG immunised guinea pigs incited a macrophage response and reticulin fibrosis. The immunised animals showed a more rapid localisation of pulmonary lesions and disappearance of the chrysotile fibres leading to accelerated focal fibrosis. More rap...

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Bibliographic Details
Published inIndustrial Health Vol. 20; no. 2; pp. 129 - 137
Main Authors ZAIDI, S.H., BHATTACHERJEE, J. Wynne, DOCRA, R.K.S., SAXENA, R.P.
Format Journal Article
LanguageEnglish
Published Japan National Institute of Occupational Safety and Health 1982
Subjects
Animals
Asbestos - adverse effects
Asbestos, Serpentine
Asbestosis
Asbestosis - etiology
BCG
BCG Vaccine - pharmacology
Guinea Pigs
Intubation, Intratracheal
Lung - pathology
Macrophage Activation - drug effects
Male
Pulmonary Fibrosis - etiology
Time Factors
Tissue Distribution
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Summary:Chrysotile inoculated intratracheally into normal and BCG immunised guinea pigs incited a macrophage response and reticulin fibrosis. The immunised animals showed a more rapid localisation of pulmonary lesions and disappearance of the chrysotile fibres leading to accelerated focal fibrosis. More rapid transport of chrysotile to the lymph nodes of immunised animals was also observed. These findings suggest that BCG vaccine can influence the development of pathological lesions of asbestosis in guinea pigs by inducing them earlier and more rapidly.
ISSN:0019-8366
1880-8026
DOI:10.2486/indhealth.20.129