Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct

• Published in: The New England journal of medicine Vol. 388; no. 14; pp. 1272 - 1283
• Main Authors: Huo, Xiaochuan, Ma, Gaoting, Tong, Xu, Zhang, Xuelei, Pan, Yuesong, Nguyen, Thanh N., Yuan, Guangxiong, Han, Hongxing, Chen, Wenhuo, Wei, Ming, Zhang, Jiangang, Zhou, Zhiming, Yao, Xiaoxi, Wang, Guoqing, Song, Weigen, Cai, Xueli, Nan, Guangxian, Li, Di, Wang, A. Yi-Chou, Ling, Wentong, Cai, Chuwei, Wen, Changming, Wang, En, Zhang, Liyong, Jiang, Changchun, Liu, Yajie, Liao, Geng, Chen, Xiaohui, Li, Tianxiao, Liu, Shudong, Li, Jinglun, Gao, Feng, Ma, Ning, Mo, Dapeng, Song, Ligang, Sun, Xuan, Li, Xiaoqing, Deng, Yiming, Luo, Gang, Lv, Ming, He, Hongwei, Liu, Aihua, Zhang, Jingbo, Mu, Shiqing, Liu, Lian, Jing, Jing, Nie, Ximing, Ding, Zeyu, Du, Wanliang, Zhao, Xingquan, Yang, Pengfei, Liu, Liping, Wang, Yilong, Liebeskind, David S., Pereira, Vitor M., Ren, Zeguang, Wang, Yongjun, Miao, Zhongrong
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 06.04.2023
• Subjects: Blood clots; Brain Ischemia - drug therapy; Brain Ischemia - surgery; Cardiovascular system; Cerebral blood flow; Cerebral infarction; Cerebral Infarction - drug therapy; Cerebral Infarction - surgery; China; Computed tomography; Disease management; Emergency Medicine; Endovascular Procedures - adverse effects; Endovascular Procedures - methods; Fibrinolytic Agents - adverse effects; Fibrinolytic Agents - therapeutic use; Hemorrhage; Humans; Intracranial Hemorrhages - chemically induced; Intracranial Hemorrhages - etiology; Ischemia; Ischemic Stroke - drug therapy; Ischemic Stroke - surgery; Magnetic resonance imaging; Medical imaging; Neurology; Neurosurgery; Patients; Population studies; Prospective Studies; Radiology; Radiology General; Software; Stroke; Stroke - drug therapy; Stroke - surgery; Thrombectomy - adverse effects; Thrombectomy - methods; Thrombolysis; Thrombolytic drugs; Tomography; Treatment Outcome; Veins & arteries; China; Japan
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2213379

In a trial conducted in China, patients with large cerebral infarctions as determined by imaging criteria within 24 hours after onset had better outcomes with endovascular therapy than with medical therapy alone.