An improved process for the preparation of pimavanserin tartrate

A practical synthetic route to pimavanserin tartrate, in which the target compound was obtained with 99.84% purity and in 46% total yield via a 5-step synthesis starting from 4-hydroxybenzaldehyde and (4-fluorophenyl)methanamine, is reported. The main advantages of the route include inexpensive star...

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Bibliographic Details
Published inJournal of chemical research Vol. 43; no. 11-12; pp. 480 - 485
Main Authors Wu, Caijiao, Zhou, Qifan, Song, Dake, Li, Hui, Bao, Changshun, Liu, Xuelong, Bao, Xuefei, Chen, Guoliang
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.11.2019
Sage
Sage Publications Ltd
Subjects
Chemical synthesis
Chemistry
Chemistry, Multidisciplinary
Hydroxybenzaldehydes
Physical Sciences
Science & Technology
Solvents
synthesis
5-HT2A receptors
optimization
pimavanserin tartrate
Parkinson’s disease
Parkinson's disease
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Summary:A practical synthetic route to pimavanserin tartrate, in which the target compound was obtained with 99.84% purity and in 46% total yield via a 5-step synthesis starting from 4-hydroxybenzaldehyde and (4-fluorophenyl)methanamine, is reported. The main advantages of the route include inexpensive starting materials, mild reaction conditions and an acceptable overall yield.
ISSN:1747-5198
2047-6507
DOI:10.1177/1747519819873643