A New Noninvasive System for Clinical Pulse Wave Velocity Assessment: The Athos Device

• Published in: IEEE transactions on biomedical circuits and systems Vol. 15; no. 1; pp. 133 - 142
• Main Authors: Buraioli, Irene, Lena, Davide, Sanginario, Alessandro, Leone, Dario, Mingrone, Giulia, Milan, Alberto, Demarchi, Danilo
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.02.2021; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Algorithms; Arterial pulse; arterial stiffness; Electrocardiography; Graphical user interface; intersecting tangent algorithm; Microelectromechanical systems; Micromechanical devices; Portable computers; Probes; pulse transit time; pulse wave velocity; Quality; Sensors; Signal processing; Software; tonometry; Velocity; Wave velocity
• ISSN: 1932-4545; 1940-9990; 1940-9990
• DOI: 10.1109/TBCAS.2021.3058010

This paper presents a low cost, noninvasive, clinical-grade Pulse Wave Velocity evaluation device. The proposed system relies on a simultaneous acquisition of femoral and carotid pulse waves to improve estimation accuracy and correctness. The sensors used are two high precision MEMS force sensors, encapsulated in two ergonomic probes, and connected to the main unit. Data are then wirelessly transmitted to a standard laptop, where a dedicated graphical user interface (GUI) runs for analysis and recording. Besides the interface, the Athos system provides a Matlab algorithm to process the signals quickly and achieve a reliable PWV assessment. To better compare the results at the end of each analysis, a detailed report is generated, including all the relevant examination information (subject data, mean PTT, and obtained PWV). A pre-clinical study was conducted to validate the system by realizing several Pulse Wave Velocity measurements on ten heterogeneous healthy subjects of different ages. The collected results were then compared with those measured by a well-established and largely more expensive clinical device (SphygmoCor).