Hormonal and nutritional regulation of muscle carnitine palmitoyltransferase I gene expression in vivo

• Published in: Archives of biochemistry and biophysics Vol. 465; no. 2; pp. 437 - 442
• Main Authors: Liu, Hong Yan, Zheng, Guolu, Zhu, Hongfa, Woldegiorgis, Gebre
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2007
• Subjects: Animals; Carnitine O-Palmitoyltransferase - metabolism; CAT; Diabetes Mellitus, Experimental - metabolism; Dietary; Dietary Fats - metabolism; Fasting - metabolism; Female; Gene expression; Gene Expression Regulation, Enzymologic; Hormonal; Hormones - metabolism; M-CPTI; Male; Mice; Mice, Transgenic; Muscle, Skeletal - metabolism; Organ Specificity; Promoter; Regulation; Tissue Distribution; Transgenic mice; Promoter; CAT; Transgenic mice; Hormonal; Regulation; M-CPTI; Gene expression; Dietary

Transgenic mice carrying the human heart muscle carnitine palmitoyltransferase I (M-CPTI) gene fused to a CAT reporter gene were generated to study the regulation of M-CPTI gene expression. When the mice were fasted for 48 h, CAT activity and mRNA levels increased by more than 2-fold in heart and sk...