Determining the solubility of synthomycin in solid dispersions

The influence of solid dispersions (SDs) on the solubility of synthomycin (INN chloramphenicol) has been determined. SDs of synthomycin with poly(ethyleneglycol) (PEG-1500), poly(vinylpyrrolidone) (PVP-10000), and β-cyclodextrin have been obtained and studied. The solubility of synthomycin from SDs...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 44; no. 1; pp. 25 - 32
Main Author Krasnyuk, I. I. Jr
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.05.2010
Springer US
Springer
Subjects
Chemical properties
Cyclodextrins
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
solid dispersions
solubility
synthomycin (chloramphenicol)
synthomycin (chloramphenicol)
solubility
solid dispersions
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Summary:The influence of solid dispersions (SDs) on the solubility of synthomycin (INN chloramphenicol) has been determined. SDs of synthomycin with poly(ethyleneglycol) (PEG-1500), poly(vinylpyrrolidone) (PVP-10000), and β-cyclodextrin have been obtained and studied. The solubility of synthomycin from SDs increases by a factor of 1.5-2.0; the solubility rate, 2.7-3.4, as compared to those for the parent substance. Data obtained by a combination of physicochemical methods indicate that the improved release of synthomycin from SDs is related to a decrease in the degree of crystallinity and to the formation of intermolecular complexes.
Bibliography:http://dx.doi.org/10.1007/s11094-010-0390-0
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0390-0