High-throughput screening of the chemical composition distribution of random styrene-butyl acrylate copolymers

The development of high-throughput liquid chromatographic techniques for the analysis of styrene-butyl acrylate (SBA) copolymers is discussed. The analysis time in size-exclusion chromatography (SEC) can be reduced to about 3 min per sample when high-throughput SEC columns and high flow rates are us...

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Bibliographic Details
Published ine-Polymers Vol. 5; no. 1; pp. 433 - 445
Main Authors Romero, Iván García, Pasch, Harald
Format Journal Article
LanguageEnglish
Published De Gruyter 01.12.2005
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Summary:The development of high-throughput liquid chromatographic techniques for the analysis of styrene-butyl acrylate (SBA) copolymers is discussed. The analysis time in size-exclusion chromatography (SEC) can be reduced to about 3 min per sample when high-throughput SEC columns and high flow rates are used. In gradient HPLC, small columns with improved separation efficiencies can be applied. The time requirements can be decreased to less than 2 min per sample. Using the high-throughput HPLC technique, the chemical composition distribution of high-conversion SBA copolymers can be analyzed in a fast and efficient way. The calibration of HPLC separation is conducted by coupling the HPLC system with FTIR through the LC-transform interface. A comparison of the chemical compositions of the copolymers obtained by H NMR, off-line FTIR and coupled HPLCFTIR verifies the accuracy of the high-throughput copolymer analysis approach.
ISSN:2197-4586
1618-7229
1618-7229
DOI:10.1515/epoly.2005.5.1.433