A New Segmented Virus Associated with Human Febrile Illness in China

• Published in: The New England journal of medicine Vol. 380; no. 22; pp. 2116 - 2125
• Main Authors: Wang, Ze-Dong, Wang, Bo, Wei, Feng, Han, Shu-Zheng, Zhang, Li, Yang, Zheng-Tao, Yan, Yan, Lv, Xiao-Long, Li, Liang, Wang, Shu-Chao, Song, Ming-Xin, Zhang, Hao-Ji, Huang, Shu-Jian, Chen, Jidang, Huang, Fu-Qiang, Li, Shuang, Liu, Huan-Huan, Hong, Jian, Jin, Yu-Lan, Wang, Wei, Zhou, Ji-Yong, Liu, Quan
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 30.05.2019
• Subjects: Adult; Aged; Animals; Antibodies; Arachnids; Cell culture; China - epidemiology; Communicable Diseases, Emerging - epidemiology; Communicable Diseases, Emerging - virology; Electron microscopy; Encephalitis; Fatigue - etiology; Female; Fever; Fever - etiology; Flaviviridae - classification; Flaviviridae - genetics; Flaviviridae - isolation & purification; Flaviviridae - ultrastructure; Genomes; Headache; Headache - etiology; Headaches; Health surveillance; Hospitalization; Hospitals; Humans; Illnesses; Immunofluorescence; Infections; Insect bites; Leptospirosis; Male; Microscopy; Microscopy, Electron; Middle Aged; Mosquitoes; Nucleotide sequence; Pathogens; Patients; Phylogeny; Polymerase chain reaction; R&D; Research & development; Reverse Transcriptase Polymerase Chain Reaction; RNA viruses; Seroconversion; Symptom Assessment; Tick-borne diseases; Tick-Borne Diseases - complications; Tick-Borne Diseases - epidemiology; Tick-Borne Diseases - virology; Ticks - virology; Viral infections; Virology; Viruses; China; Inner Mongolia China
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa1805068

A group of patients with a febrile illness and a history of tick bites was identified in northeastern China. A previously unknown virus was determined to be a possible etiologic agent. This virus was also found in ticks in the area.