Serum levels of alpha-1-antitrypsin in individuals with different Pi M subtypes

Individuals with heterozygous Pi M subtypes were found to have higher serum levels of alpha 1-antitrypsin (alpha 1-AT) than homozygotes. The alpha 1-AT levels in heterozygotes showed a unimodal distribution. Among homozygotes, a tendency towards a bimodal distribution was found. The mechanism behind...

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Bibliographic Details
Published inHuman heredity Vol. 30; no. 2; p. 81
Main Authors Beckman, G, Beckman, L
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1980
Subjects
alpha 1-Antitrypsin - genetics
Genetic Variation
Heterozygote
Homozygote
Humans
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Summary:Individuals with heterozygous Pi M subtypes were found to have higher serum levels of alpha 1-antitrypsin (alpha 1-AT) than homozygotes. The alpha 1-AT levels in heterozygotes showed a unimodal distribution. Among homozygotes, a tendency towards a bimodal distribution was found. The mechanism behind this difference is not known. The result can apparently not be explained as the result of a hitherto undiscovered deficiency gene.
ISSN:0001-5652
DOI:10.1159/000153106