Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 66; no. 4; pp. 1042 - 1047
• Main Authors: Mishra, A.K., Mishra, S.B., Manav, N., Kumar, R., Sharad, Chandra, R., Saluja, D., Kaushik, N.K.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.04.2007
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Cell Death - drug effects; Characterization; Cytototoxic and Antibacterial; Diamines - chemical synthesis; Diamines - chemistry; Diamines - pharmacology; Electrons; HeLa Cells; Humans; Hydrazines - chemical synthesis; Hydrazines - chemistry; Hydrazines - pharmacology; Hydrazones - chemical synthesis; Hydrazones - chemistry; Hydrazones - pharmacology; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Organoplatinum Compounds - chemical synthesis; Organoplatinum Compounds - chemistry; Organoplatinum Compounds - pharmacology; Spectral; Spectrophotometry, Infrared; Staphylococcus - drug effects; Synthesis; Characterization; Spectral; Synthesis; Cytototoxic and Antibacterial
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2006.04.038

Some platinum (IV) complexes [Pt(L) 2Cl 2] [where, L = 2-aminopyridine- N-thiohydrazide (L 1), (2-aminopyridine- N-thio)-1,3-propanediamine (L 2), benzaldehyde-2-aminopyridine- N-thiohydrazone (L 3) and salicylaldehyde-2-aminopyrtidine- N-thiohydrazone (L 4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione–thiol tautomer and coordinate as a bidentate N–S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes.