The Association of Melanoma-Associated Antigen-C Gene With Clinicopathological Characteristics and Prognosis in Breast Cancer: A Systematic Review and Meta-Analysis

• Published in: Clinical breast cancer Vol. 24; no. 1; pp. 7 - 16
• Main Authors: Lin, Xunyi, Huo, Jiaxing, Su, Hang, Xu, Yanbo, Zhang, Fenghua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2024
• Subjects: Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - genetics; Clinicopathological features; Female; Humans; Lymphatic Metastasis; MAGE-C; Melanoma - genetics; Meta-analysis; Prognosis; MM; PR; Prognosis; OR; TRiM28; OS; STAT3; MHD; Breast cancer; HR; ER; HER-2; Meta-analysis; DFS; CTA; MAGE-C; NOS; Clinicopathological features; MAGE-C2; MAGE-C1; MFS; RFS
• ISSN: 1526-8209; 1938-0666
• DOI: 10.1016/j.clbc.2023.09.017

To investigate the correlation of melanoma-associated antigen-C gene expression with clinicopathologic characteristics and prognosis in patients with breast cancer through a meta-analysis. PubMed, Embase, Web of Science, Cochrane, CNKI, Wanfang and VIP databases were searched from the establishment of the databases to December 2022. The New castle-Ottawa Scale (NOS) was used for literature quality evaluation, and meta-analysis of all studies was performed using Rev Man 5.3 and Stata14.0. A total of 11 studies and 1146 samples were included in the meta-analysis. High expression of MAGE-C gene was significantly correlated with tumor grade (OR = 8.06, 95%CI:4.14-15.67, P < .00001), lymph node metastasis (OR = 8.06, 95%CI:4.14-15.67, P < .00001), tumor type (OR = 0.36, 95%CI: 0.23-0.49, P < .00001), tumor stage (OR = 0.14, 95%CI: 0.05-0.38, P = .0001<.05), ER expression (OR = 0.14, 95%CI: 0.05-0.38, P = .0001<.05), HER-2 expression (OR = 0.24, 95%CI:0.11-0.57, P = .001<.05) and tumor embolus (OR = 0.24, 95%CI:0.11-0.57, P = .001<.05). In addition, the MAGE-C expression was correlated with the reduced overall survival (HR = 2.13, 95%CI: 1.52-2.99, P < .0001), recurrence-free survival (HR = 2.59, 95%CI:1.47-4.56, P = .0010) and metastasis-free survival (OR = 2.52, 95%CI: 1.38-4.59, P = .003). The high expression of MAGE-C gene is closely related to some clinicopathological parameters and poor prognosis of breast cancer, which may be used as a potential biomarker to determine the prognosis of breast cancer.