Analytical Studies on Antileprous Drugs. V. On the Metabolic Difference of Promin and 4, 4'-Diaminodiphenyl Sulfone in the Urine and Plasma of Rabbits
Metabolic difference between Promin and 4, 4'-diaminodiphenyl sulfone was investigated using urine and plasma of rabbits. It was clarified that Promin is metabolized mainly to N-glucoside of 4, 4'-diaminodiphenyl sulfone, receiving desulfonation. Further, N-conjugation was not clearly prov...
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| Published in | Chemical & pharmaceutical bulletin Vol. 9; no. 6; pp. 437 - 441 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
1961
Japan Science and Technology Agency |
| Online Access | Get full text |
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| Summary: | Metabolic difference between Promin and 4, 4'-diaminodiphenyl sulfone was investigated using urine and plasma of rabbits. It was clarified that Promin is metabolized mainly to N-glucoside of 4, 4'-diaminodiphenyl sulfone, receiving desulfonation. Further, N-conjugation was not clearly proved, being different from 4, 4'-diaminodiphenyl sulfone which was metabolized to mono-N-conjugates. |
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| ISSN: | 0009-2363 1347-5223 |
| DOI: | 10.1248/cpb.9.437 |