Antihypertensive treatment is associated with improved left ventricular geometry: the Rotterdam Study
Purpose Left ventricular hypertrophy (LVH) increases the risk of cardiovascular disease. We evaluated the association between antihypertensive therapy and echocardiographically determined LVH. Methods and results The Rotterdam Study is a population‐based prospective cohort study among 7983 participa...
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Published in | Pharmacoepidemiology and drug safety Vol. 13; no. 10; pp. 703 - 709 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.10.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose
Left ventricular hypertrophy (LVH) increases the risk of cardiovascular disease. We evaluated the association between antihypertensive therapy and echocardiographically determined LVH.
Methods and results
The Rotterdam Study is a population‐based prospective cohort study among 7983 participants aged 55 years or over. Echocardiography was performed in 2823 participants. The study population consisted of 740 participants with grade 1 hypertension or antihypertensive monotherapy, without heart failure. Of these, 646 had an adequate echocardiogram for analysis of relative wall thickness (RWT) and 642 for left ventricular mass index. Participants were followed from 1 January 1991 until the date of echocardiography, between September 1992 and June 1993. Outcome measures were defined as being in the highest gender‐specific quintile of left ventricular mass index and as having a RWT higher than 0.43. A Cox regression model with duration of use of antihypertensives defined as time‐dependent covariates was used for data‐analysis. Antihypertensive treatment lowered the risk of increased left ventricular mass index (RR 0.6, 95%CI 0.4–0.9). ACE‐inhibitors, diuretics and β‐blockers all showed a risk reduction. Use of antihypertensives was also associated, although non‐significantly, with a decrease of high RWT (RR 0.8, 95%CI 0.6–1.0). ACE‐inhibitors, β‐blockers and calcium antagonists showed similar risk reductions, while diuretics seemed to increase the risk, possibly by reducing left ventricular end diastolic diameter.
Conclusions
The use of antihypertensive drugs is associated with a decreased risk of echocardiographically determined LVH in a population‐based setting. Copyright Copyright © 2004 John Wiley & Sons, Ltd. |
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Bibliography: | istex:4C288C76395F43AE1C7DCFFC5ED4F537A23CE329 No conflict of interest was declared. ark:/67375/WNG-RLNZL4K6-Q ArticleID:PDS947 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1053-8569 1099-1557 |
DOI: | 10.1002/pds.947 |