Investigations on a flexible prolyl-endopeptidase inhibitor in solution by NMR techniques

4‐Phenylbutyrylprolylpyrrolidine, an inhibitor of prolyl‐endopeptidase, exists in solution as an equilibrium of trans and cis prolyl rotamers. The equilibrium ratio and the exchange rate of the rotamers were measured in several solvents. The conformational preferences of the flexible molecule were s...

Full description

Saved in:
Bibliographic Details
Published inMagnetic resonance in chemistry Vol. 37; no. 5; pp. 346 - 352
Main Authors Podányi, Benjamin, Bokotey, Sándor, Kánai, Károly, Fehér, Miklós, Hermecz, István
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.05.1999
Subjects
13C NMR
1H NMR
conformational analysis
coupling constant
NMR
NOESY
prolyl-endopeptidase inhibitor
prolylpyrrolidine
ring-current shift
Online AccessGet full text

Cover

More Information
Summary:4‐Phenylbutyrylprolylpyrrolidine, an inhibitor of prolyl‐endopeptidase, exists in solution as an equilibrium of trans and cis prolyl rotamers. The equilibrium ratio and the exchange rate of the rotamers were measured in several solvents. The conformational preferences of the flexible molecule were studied by NMR, based on proton–proton vicinal coupling constants, NOESY cross peak intensities and aromatic ring current shifts. Copyright © 1999 John Wiley & Sons, Ltd.
Bibliography:ark:/67375/WNG-K9ZBDW88-B
istex:25C8D14CE49247BC6F6C01EA528FE3D9DA79DF7F
ArticleID:MRC466
ISSN:0749-1581
1097-458X
DOI:10.1002/(SICI)1097-458X(199905)37:5<346::AID-MRC466>3.0.CO;2-W