Autoantibodies to leucocyte antigens in hydralazine-associated nephritis

Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative g...

Full description

Saved in:
Bibliographic Details
Published inJournal of internal medicine Vol. 231; no. 1; p. 37
Main Authors Almroth, G, Eneström, S, Hed, J, Samuelsson, I, Sjöström, P
Format Journal Article
LanguageEnglish
Published England 01.01.1992
Subjects
Antibodies, Antinuclear - analysis
Female
Glomerulosclerosis, Focal Segmental - chemically induced
Glomerulosclerosis, Focal Segmental - immunology
HLA Antigens - immunology
Humans
Hydralazine - adverse effects
Male
Middle Aged
Nephritis, Interstitial - chemically induced
Nephritis, Interstitial - immunology
Neutrophils - immunology
Peroxidase - immunology
Online AccessGet more information

Cover

More Information
Summary:Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative glomerulonephritis in 10 patients, and tubulo-interstitial nephritis in five patients. Antinuclear antibody (ANA) was found in 16 patients, but none of the 14 patients tested had antibodies to DNA. Tests for antibodies to myeloperoxidase (anti-MPO) and antibodies to neutrophil cytoplasm antigen (ANCA) were performed by ELISA. Twelve of the 14 patients tested had anti-MPO; five of these 14 patients had ANCA, while one had borderline levels. These findings suggest that hydralazine facilitates the induction of a systemic disease with multiple autoantibody production.
ISSN:0954-6820
DOI:10.1111/j.1365-2796.1992.tb00496.x