Depressed Functional and Phenotypic Properties of T but not B Lymphocytes in Idiopathic Thrombocytopenic Purpura
Chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which the abnormality in cellular immunity has remained only vaguely defined. Previously we have shown that patients with ITP in its active phase have abnormal T cell subsets. We then examined the phenotypes of T and B ly...
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Published in | Blood Vol. 71; no. 5; pp. 1455 - 1460 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
Elsevier Inc
01.05.1988
The Americain Society of Hematology |
Subjects | |
Online Access | Get full text |
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Summary: | Chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which the abnormality in cellular immunity has remained only vaguely defined. Previously we have shown that patients with ITP in its active phase have abnormal T cell subsets. We then examined the phenotypes of T and B lymphocytes in an additional 28 patients with ITP and 32 age- and sex-matched normal controls and compared the lymphocytes’ capacity to respond to poly-clonal T, T cell-dependent B, and B cell mitogens. Blastogenesis to optimal (5.0 μg/mL) and suboptimal (0.5 μg/mL) concentrations of the polyclonal T cell mitogens were markedly depressed in patients compared with normal controls (P <. 0005). Similarly, a severe depression in response was noted with the polyclonal T cell-dependent B cell mitogen [P < .000001). No difference was seen, however, with the polyclonal B cell mitogen. The proportions of pan-T and T helper/inducer lymphocytes were significantly depressed (P < .005 and P < .000005 respectively), and the T suppressor /cytotoxic lymphocytes increased (P < .02) in patients relative to controls. But there was no difference in the proportion of B lymphocytes or in their functional response. The abnormal cellular immunity appears to be due to a defect in the T lymphocyte population without involvement of the B lymphocytes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-4971 1528-0020 |
DOI: | 10.1182/blood.V71.5.1455.1455 |