Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project

• Published in: The American journal of clinical nutrition Vol. 111; no. 6; pp. 1259 - 1266
• Main Authors: Alonso-Pedrero, Lucia, Ojeda-Rodríguez, Ana, Martínez-González, Miguel A, Zalba, Guillermo, Bes-Rastrollo, Maira, Marti, Amelia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020; Oxford University Press; American Society for Clinical Nutrition, Inc
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; Cross-Sectional Studies; Diet; Evaluation; Fast Foods - adverse effects; Female; Follow-Up Studies; Food; Food consumption; Food processing; Geriatrics; Health risks; Humans; Male; Middle Aged; Older people; Oxidation; Processed foods; Prospective Studies; Quartiles; Regression analysis; Regression models; Risk; Saliva; Spain; SUN cohort; Telomerase; Telomere - genetics; Telomere - metabolism; telomere length; Telomere Shortening; Telomeres; ultra-processed food; Spain; CVD; SUN cohort; ultra-processed food; SSB; TL; UPF; diet; SUN; telomere length; cross-sectional studies
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/nqaa075

Telomere length (TL) is a marker of biological age that may be affected by dietary factors through oxidation and inflammation mechanisms. In addition, ultra-processed food (UPF) consumption has increased worldwide and it has been associated with the risk of developing several diseases. We aimed to evaluate the association between UPF consumption and the risk of having short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project. This is a cross-sectional study of 886 participants (645 men and 241 women) aged 57–91 y recruited from the SUN Project (Spain, 1999–2018). TL was measured from saliva samples by real-time qPCR at baseline and UPF consumption was collected using a validated 136-item FFQ and classified according to the NOVA system. We evaluated the association between consumption of energy-adjusted UPF categorized into quartiles (low, medium-low, medium-high, and high consumption) and the risk of having short telomeres (<20th percentile) using logistic regression models. Those participants with the highest UPF consumption had almost twice the odds of having short telomeres compared with those with the lowest consumption (adjusted OR: 1.82; 95% CI: 1.05, 3.22; P-trend = 0.03). A higher consumption of UPF (>3 servings/d) was associated with higher risk of having shorter telomeres in an elderly Spanish population of the SUN Project. This trial was registered at clinicaltrials.gov as NCT02669602.