Transforming Growth Factor-β1 to the Bone

• Published in: Endocrine reviews Vol. 26; no. 6; pp. 743 - 774
• Main Authors: Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.10.2005; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Angiogenesis; Biological and medical sciences; Bone growth; Bone healing; Bone resorption; Bone turnover; Cell differentiation; Cell migration; Cell survival; Embryogenesis; Embryonic growth stage; Fundamental and applied biological sciences. Psychology; Growth factors; Osteogenesis; Transforming growth factor-b1; Vertebrates: endocrinology; Wound healing; Osteoarticular system; Review; Transforming growth factor β1; Bone
• ISSN: 0163-769X; 1945-7189
• DOI: 10.1210/er.2004-0001

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-β1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-β1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-β1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.