Copper homeostasis and cuproptosis in gynecological cancers

Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death. Cu targets lipo...

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Published inFrontiers in cell and developmental biology Vol. 12; p. 1459183
Main Authors Huang, Xiaodi, Lian, Mengyi, Li, Changzhong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 25.09.2024
Subjects
Cell and Developmental Biology
copper homeostasis
copper ionophore
cuproptosis
functional analysis
gynecological cancers
prognosis prediction
cuproptosis
copper ionophore
gynecological cancers
copper homeostasis
prognosis prediction
functional analysis
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Summary:Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death. Cu targets lipoylated enzymes in the tricarboxylic acid cycle and subsequently triggers the oligomerization of lipoylated dihydrolipoamide S-acetyltransferase, leading to the loss of Fe-S clusters and induction of heat shock protein 70. Gynecological malignancies including cervical cancer, ovarian cancer and uterine corpus endometrial carcinoma significantly impact women's quality of life and even pose a threat to their lives. Excessive Cu can promote cancer progression by enhancing tumor growth, proliferation, angiogenesis and metastasis through multiple signaling pathways. However, there are few studies investigating gynecological cancers in relation to cuproptosis. Therefore, this review discusses Cu homeostasis and cuproptosis while exploring the potential use of cuproptosis for prognosis prediction as well as its implications in the progression and treatment of gynecological cancers. Additionally, we explore the application of Cu ionophore therapy in treating gynecological malignancies.
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Ruidi Yu, Huazhong University of Science and Technology, China
Edited by: Ming Yi, Zhejiang University, China
Reviewed by: Qian Yang, Zhejiang University, China
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2024.1459183