The protective effects of echinochrome A structural analogs against oxidative stress and doxorubicin in AC16 cardiomyocytes

Backgrounds Echinochrome A (6-ethyl-2,3,5,7,8-pen-tahydroxy-1,4-naphthoquinone) is a common naphthoquinone pigment found in the shells, spines, and coelomic fluid of sea urchins. We previously reported that echinochrome A has a cardioprotective function as an antioxidant against reactive oxygen spec...

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Published inMolecular & cellular toxicology Vol. 15; no. 4; pp. 407 - 414
Main Authors Yoon, Chang Shin, Kim, Hyoung Kyu, Mishchenko, Natalia P., Vasileva, Elena A., Fedoreyev, Sergey A., Shestak, Olga P., Balaneva, Nadezhda N., Novikov, Vyacheslav L., Stonik, Valentin A., Han, Jin
Format Journal Article
LanguageEnglish
Published Incheon The Korean Society of Toxicogenomics and Toxicoproteomics 01.10.2019
Springer Nature B.V
대한독성 유전단백체 학회
Subjects
Antioxidants
Biomedical and Life Sciences
Butyl hydroperoxide
Cardiomyocytes
Cell Biology
Doxorubicin
Life Sciences
Original Paper
Oxidative stress
Oxygen consumption
Pharmacology/Toxicology
Reactive oxygen species
Spines
생물학
Structural analogs
Echinochrome A
Doxorubicin
Cardioprotective effect
Spinochromes
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Summary:Backgrounds Echinochrome A (6-ethyl-2,3,5,7,8-pen-tahydroxy-1,4-naphthoquinone) is a common naphthoquinone pigment found in the shells, spines, and coelomic fluid of sea urchins. We previously reported that echinochrome A has a cardioprotective function as an antioxidant against reactive oxygen species (ROS) induced by tert-Butyl hydroperoxide and doxorubicin. Methods In the current study, we evaluated the antioxidant activity, ATP production, and oxygen consumption rate (OCR) of seven echinochrome structural analogs (spinochromes) in AC16 human cardiomyocyte cells. The compounds included in the study had various substituents including hydroxyl (Sp B and Sp E), amino (Echm A), methoxyl (TriMeEch A), pentyl (No. 284), and hydroxypentyl (No. 285). We also investigated the effects of one dimeric spinochrome (Binaphthoquinone). Results Spinochromes exhibited enhanced antioxidant activity and ATP production. Interestingly, the hydroxylated compounds significantly enhanced the OCR and had a cardiomyocyte protective effect in the presence of doxorubicin. Conclusion Our findings indicate that echinochrome A structural analogs may have therapeutic potential for cardio-protection.
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-019-0044-6